Log in
My story with 23andmeMy story with diagnosed diseasesLatest DiscussionOpen CurationCuration Log

Why GeneKnot?

GeneKnot provides search results from publicly available scientific research using your direct-to-consumer genetic data (Disease Risk). GeneKnot also uses a subset of SNPs related to diseases to calculate genetic distances to find people with similar genetic variants (GeneKnot menu). Please note that this approach using genetic similarities is highly experimental and there is ABSOLUTELY NO GUARANTEE FOR THE CORRECTNESS. GeneKnot allows estimation of your genetic distances from users with diagnosed, high risk, family history, relevant, or concerned diseases to share the experience.

Privacy Policy

You need to agree to the terms and conditions while you register. Please use an anonymous or generic user id that is not associated with your personal information. We care about protecting personal information. In GeneKnot, you don't need to reveal your information except your age and diseases. Your data will be analyzed only when it needs to be updated in GeneKnot.

GeneKnot uses 3 simple steps:

To use GeneKnot you should have DTC results like 23andme. If you have not joined 23andme, you can do it on 23andMe website. We're not affiliated with 23andme. If you have 23andme results, the zipped file can be downloaded here. You can upload a zipped or unzipped file to GeneKnot. We recommend that you rename your file for data privacy.

1. Upload your file (and update user information) in "Genome Upload" (Please register with an anonymous user ID for data privacy)

2. Check your risk in "Disease Risk" and "My Obesity". The analysis may take about one hour or more.

3. In "GeneKnot" menu, each circle represents one person. If DNA variants of other users are close to yours, they will be near your circle. These DNA variants are known to be associated with a particular disease. Relative genetic distances are shown, but your SNPs are not visible for data privacy as of 2/1/2015. If you can find people like you in DNA variants, click the circle for the person. You can click a user profile in a pop-up window and find user information including ages and diagnosed diseases. (It may take up to 24 hours for your circle to show in Geneknot depending on resources; Optimized for Chrome and Firefox)

You can send messages, tweet, blog, and make groups for your diseases of interest.

Disclaimer about the data

Disease risk is based on the published data in National Genome Research Institute. Most data are from users in GeneKnot.com. We also use the published genomes in personalgenomes.org and opensnp.org and some data may not have active users or profiles. If many users provide their ages and diagnosed diseases, we plan to support the summary report on disease progression of different age groups with similar genetic risk. This approach is still highly experimental and there is ABSOLUTELY NO GUARANTEE FOR THE CORRECTNESS. Please use this site at your own risk and talk with professionals for further actions.

About us

We are scientists/engineers in Silicon Valley. Please contact GeneKnot (contact(AT)geneknot(DOT)com) if you have any questions.


We'd like to thank users who shared their valuable data in GeneKnot.com, personalgenomes.org and openSnp.org.


GeneKnot uses an open source graphic visualization tool (Gephi) under the following terms:
Copyright (C) 2011 by Raphaël Velt Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions: THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.

Copyright (C) 2013-2015 by GeneKnot