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Curation Log

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By geneknot 1457 days ago

Curation will be updated here.

7/11/2016: There are two options to select during file upload: The 1st option (default) is that raw data will be deleted after the analysis (typically within 48 hrs). Analyzed results will be deleted after one month. This option is for users who want more strict data protection. The 2nd option is that raw data will be deleted, but analyzed results ("Disease risk" and "GeneKnot" menu) will be stored in GeneKnot. Any raw data and "Disease risk" results older than 3 months without the selected options in Genome Upload will be deleted for data protection. 

6/23/2015: Discontinue "My genome news" until more resources are available. 

6/18/2015, 5/5/2015: Removed non-informative diseases from "GeneKnot"; It will be presented when more information is available.

4/14/2015: Disease Risk (new) discontinued for database maintenance; All results are available in Disease Risk  

3/31/2015: Started "My Obesity" to assess your genetic factors in obesity using effect alleles associated with body mass index. The positive correlation between the number of effect alleles and body mass index is reported in the study published in Nature. 

3/14/2015 (updated on 7/11/16): Two options for data storage are provided:

1) The 1st option (default) is that raw data will be deleted after the analysis (typically within 48 hrs). The analyzed data will be also deleted after one month. This option is for users who want more strict data protection.  

2) The 2nd option is that analysis results will be stored in GeneKnot. But raw data will be deleted after analysis. 

2/16/2015: Started "My Genome News" to provide recent GWAS news related to your data

2/8/2015: Two SNPs (rs3883013, rs3853444) studied from Lithuanian families (http://www.ncbi.nlm.nih.gov/pubmed/24778558?dopt=Abstract) are excluded in the analysis since other races  have the risk allele (G) in a high frequency. They may overestimate Coronary heart diease risk (7.7-29 times). Updates in progress. Related links: http://www.snpedia.com/index.php/Rs3883013http://www.snpedia.com/index.php/Rs3853444

2/5/2015: In Alzheimer's disease, the effect of APOE variants (rs7412 and rs429358) is added based on http://www.ncbi.nlm.nih.gov/pubmed/11136203?dopt=Abstract (age 65 or later). The risk may vary depending on race, sex and age. Here we report the relative risk from Table 2 in the reference. Please note that this risk can increase up to 9-11 in odds ratio (according to 23andme or snpedia) for users with homozygous APOE ɛ4 variants. Read more about APOE. The possible numbers of APOE ɛ4 variants are shown as CC (2; homozygous), CN (1: heterozygous) and NoRiskAllele (0). Users who uploaded the data before 2/5/2015 would see this result after our next update. 

2/1/2015: To increase data protection and privacy, individual SNPs for users are not shown in GeneKnot menu.  

12/19/2014: SNPs for Atopic dermatitis and Asthma combined for GeneKnot menu and marked "blue" for Asian users / Asian users marked "blue" in Hypothyroidism

12/18/2014: SNPs for Celiac disease were updated for better separation between diagnosed and undiagnosed users & between Caucasian/other races and Asian.   

12/13/2014: SNPs for Breast cancer were updated for better separation between diagnosed and undiagnosed users & between Caucasian/other races and Asian.   

12/7/2014: SNPs reported in reverse strands (dbSNP141) are included in "Disease Risk"  (~18% of total 23andme SNPs). The results in "GeneKnot" will be updated with new information. The users who upload the data after 12/7/2014 will see the updated results. The users with the uploaded data before 12/8/2014 would see the updated results after our next update.

8/7/2014: Asian users with two Ts in rs2200733 are not considered "High risk" in Atrial fibrillation since they are often found in Asian (TT: ~60%). Asian users are marked in blue based on the following information.

http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=2200733

Asian users also form a distinct group in Crohn's disease, Rheumatoid arthritis, Multiple Sclerosis, Type 2 diabetes and Prostate cancer (marked in blue)

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8/11/17: New users with 

Gestational Diabetes, Anxiety / deafness / fibromyalgie / asthma, pcos, anxiety / Depression, Anxiety, High Blood Pressure, Uterine Fibroids / Major depression / Arterial Sclerosis, Bladder Cancer / PCOS, Endometreosis / Hyper POTS, Lyme, MCAD / Enlarged liver / Depression, OCD, Hypoglycemia / Asthma, Endometriosis, Adenomyosis, Hypertension, Type II Diabetes, Spondylolysis, Chronic Depression with Anxiety, GERD, scoliosis, severe osteoarthritis, IBS / Depression, High Blood Pressure / Asthma / pre-diabetes, congestive heart failure, pcos, rheumatoid arthritis, osteoarthritis, sleep apnea, restless leg syndrome, endometrial hyperplasia with atypia / Collagenous Collitis, fibromyalgia, bi-polar, arthritis / hypotyroid / autoimune / postural orthostatic tachycardia syndrome, EDS, MCAS, maniers  / B12 Deficiency / Fibromyalgia, Major Depressive Disorder, Dysthymia, Anxiety, ADHD, High Cholesterol / hashimotos / hypoglycemia, PCOS, huritism / benign hypertension, hypothyroid,hodgkins lymphoma / osteoarthritis / P.C.O.S., Migraines, Depression, Bi-polar disorder, endometriosis, anxiety, hypothyroidism, O.C.D. / Prostate Cancer / Asthma / Bipolar / Depression, Fibromyalgia, Anxiety / Anxiety, Depression, ADHD, Hypertension / Aortic valve abnormality, hyptertension / AUTISM / narcolepsy, primary coenzyme q10 deficiency, psoriasis, hypercalciuria / depression, anemia / anxiety, depression / chronic rhinosinusitis / Asthma, Scoliosis / migraine, hypothyroidism, endometriosis / hyperhidrosis / inflammatory bowel disease

5/21/17: New users with Anxiety, High Blood pressure / hypertension / ADHD, PCOS, Anxiety / Autism / no / High Blood Pressure / celiac disease / Spina Bifida, PCOS, asthma / Hyper Tension / epilepsy, insomnia / Hypertension, hypogonadism / Bipolar disorder / pcos, hypersomnia, allergies / Hypertension, depression / Major Depressive Disorder, Bipolar2, Panic Disorder / hypertension / Hashimoto's Hypothyroid, Celiac Disease, Crohn's Disease, Lactose Intolerance, Patent Foramen Ovale, Diverticulosis, Adenomyosis, endometriosis / Allergic Asthma / Bipolar Disorder / PCOS / Mitral Valve Prolapse / ADHD, Migraine, Anxiety / Rheumatoid Arthritis / Autism / hypertension / type 1 diabetes, celiac disease / Heart Valve, Kidney Failure / Asthma, Endometriosis / Hashimoto's Thyroiditis / Atrial Fibrilation / Bipolar disorder, ADHD / Vericose veins, post surgical hypothyroidism / Autism, Aspergers Syndrome / Hearing Loss / Depression / Bipolar Disorder, ADHD, Hashimoto's, Lynch Syndrome, Migraines

 

3/18/17: New users with Obesity  / kawasaki / Autism Spectrum Disorder, Depression, Agoraphobia  / Cm-avm syndrome  / Primary open angle glaucoma, Raynaud's disease, Rosacea, Androgenic alopecia, Vasomotor rhinitis  / hypothyroidism / Eosinophilic Esophagitis / ADHD, depression, bipolar disorder, social anxiety / type 2 diabetes / Stroke, Diabetes 2, Hyperparathyroidism, IBS, Diverticulitis, Gastroparesis, Obesity, Kidney Disease, endometriosis

2/17/17: New users with Depression / High Blood pressure, Asperger Syndrome / Irritable Bowel Syndrome, GERD, Spinal Osteoarthritis, Fibrocystic breast disease / ADHD / psoriasis, migraine, depression / Celiac / Depression, ADHD / scoliosis, cmt / ADHD / Arthritis / Type 2 Diabetes, Atrial fibrillation, iron overload disorder, kidney stones

1/28/17: New users with Scoliosis / Frontal Lobe Meningioma / ADHD, Anemia / Type 1 Diabetes, Rosacea, cataracts, psoriasis / Depression

1/22/17: New users with Narcolepsy, hypothyroidism, bipolar   / von willebrand disease / fibromyalgia / anemia / Hypertension / Nephrolithiasis, hypercholesterolemia, Hypertension / Asthma / Type 2 diabetes, hypertension, depression, anxiety, bipolar disorder, fibromyalgia, polycystic ovarian syndrome / Breast cancer / None yet / High blood pressure, spinal stenosis  / type 2 diabetes, heart disease, fibromyalgia, chronic fatigue syndrome, high blood pressure, high cholesterol / Fibromyalgia / cholesterol / Lupus, Rheumatoid arthritis / RA / Hypothyroidism, Bipolar 3, Anxiety, Depression, OCD / High Blood Pressure, ADD / vitiligo, hypothyroid / B12 deficency, fibromyalgia,asthma,enemia,nueropathy,adhd, anxiety,depression, insomnia, peptic ulcer, reflux, gallstones, hyatel hernia,  / bipolar I, alcoholism / Ehlers-Danlos, bipolar II, hypothyroid / Crohn's disease / Acid Reflux / ADHD / ADHD, Anxiety, Heart Murmur MVP / Hashimoto's thyroiditis / diabetes / Scoliosis

12/24/16: New users with spinal stenosis, Scoliosis, arthritis  / Fibromyalgia, Metabolic Syndrome / Bipolar I / Congenital heart disease / generalized anxiety disorder, h. pylori / diabetes type 2 / Asthma, ADD, Depression,Anxiety,SIADH / epilepsy, asthma / Depression / kidney stones, tonsillectomy, obesity / Hypertriglyceridemia / asthma, anxiety, depression, insomnia (best working medications: singulair, cymbalta, cymbalta, lorazepam)

11/19/16: New user with Coronary Artery Disease

11/12/16: New users with Charcot-Marie-Tooth Disease /  thyroid nodule / Neuropathy, Restless Leg Syndrome, Paget's Disease / Depression, High Blood Pressure / asthma / Neuroblastoma, Sensioneural Hearing Loss, Idiopathic Hypersomnia / Irritable bowel syndrome / chronic fatigue syndrom / depression / hypertension, wolfe-parkinson-white / Rheumatoid Arthritis, Raynauds, Brain Tumor, RLS, Sleep Apnea  / kidney stones, depression / Celiac / Lupus, Scoliosis, Asthma / Fibromyalgia (Best working medication: Lyrica) / Anxiety, IBS / ADHD / paroxysmal dyskinesia / anxiety / Depression, General Anxiety Disorder, IBS, Fibromyalgia, Gastroesophageal Reflux Disease / Alopecia Areata, hypertension, depression, rosacea / Narcolepsy, Heart Palpitations 

9/19/16: New users with Diabetes 2, Fibromyalgia, Osteoarthritis, dissociative seizure, malabsorption Liver salts / endometriosis, diverticulosis, PCOCS, Fibroid Myalgia / EDS, IBS, Chronic Fatigue, Morton Neuroma, Pelvic Congestion, Endometriosis / Distonia

9/10/16: New users with asthma, degerative disc disease / fibromuscular dysplasia, POTS, Martin-Gruber anastomosis / IBS, Osteoarthritis, DDD, B12D

 

9/6/16: New users with Ventricular Tachycardia, Anemia, GERD / Episodic migraine, sciatica, spinal cord syrinx / hashimoto's thyroiditis, eczema, migraine, arthritis, adhd / high blood pressure, ADD, Essential Tremor, Restless Leg Syndrome, Strabismus / PTSD / Type II Diabetes, hypertension  / Lupus, Antiphoslipid antibody, hypothyroidism /asthma, bipolar disorder, depression, hyperlipidemia, obesity / Familial Mediterranean Fever, Periodic Fever Syndrome, Lupus, Asthma,BBB / Type I diabetes / Chiari Malformation Type I / psoriatic arthritis, major depression, bipolar II, hypothyroidism, hashimoto's thyroiditis, knee osteoarthritis, fibromyalgia, spondylitis, HLA-B27, chronic pain, high blood pressure, morbid obesity, tinnitus, asthma, childhood asthma, former smoker / Multiple Sclerosis

 

8/12/16: New users with SLE Lupus, high cholesterol, reflux / SLE-Lupus, Alpha 1 Anti-tyrpsin Deficiency, Hypogammaglobulinemia / Restless Leg Syndrome / depression 

7/5/16: New users with Celiac disease  / Type 2 diabetes and Hypothyroid / Hashimotos Thyroiditis, Depression, Anxiety, Social Anxiety, Attention Deficit Disorder, Excoriation disorder (BEST Working medicineLevothyroxine, Bupropion, Clonazepam, Clonazepam, AMPHETAMINE SALTS ER, SERTRALINE HCL) / Hypothyroid / Ulcerative Colitis, Hidradenitis Suppurativa, Anxiety / Breast Cancer / fibromyalgia

6/16/16: New users with hypertension, arrythmia, psoriasis / migraine / asthma, aspergers syndrome / ADHD / hyperlipedemia / rheumatoid arthritis,endometriosis,chronic urticaria 

5/4/16: A new user with Depression, Anxiety

4/28/16: New users with gallbladder disease / Choroideremia / Heart murmur, Asthma / Factor V Leiden / Premature Ovarian Failure, Depression / Hashimoto's Thyroiditis / Myocardial infarction, hypertension, asthma, myopia / Lipedema / ADHD / borderline personality disorder, non-24-hour sleep-wake disorder /  High blood pressure, osteoarthritis, Arachnoiditis / Hypothyroidism /  hypermobility syndrome, postural orthostatic tachycardia syndrome, gastroparesis, aspergers syndrome, dyslexia, dyspraxia, asthma, hayfever / Behcet's Disease, Sjogren's

3/27/16: New users with Anxiety, PTSD, obesity, depression, pre diabetes, elevated cholesterol, fibromyalgia / Syringomyelia, urticaria, arthritis, palpitations, fibromyalgia / PCOS, asthma, degenerative disc disease, allergies, autism spectrum disorder, celiac disease, depression, generalized anxiety disorder 

1/23/16: New users with bipolar, adhd / Anxiety DIsorder, OCD, Dermatillomania / Ehlers-Danlos Syndrome, Hereditary Hemochromatosis, Obsessive-Compulsive Disorder / Celiac disease, tachycardia, anxiety, depression

1/10/16: A new user with depression, anxiety, bulimia, attention deficit disorder

1/7/16: New users with scoliosis / Idiopathic Rheumatoid Arthritis / OCD, ADHD

1/4/16: New users with Arrhythmogenic right ventricular dysplasia  / obstructive sleep apnea, anxiety / Melanoma / Breast Cancer, Asthma 

 

12/23/15: New users with Crohn's disease /  hypertension, myopia /   Gluten intolerance / Rheumatioid arthritis

12/18/15: A new user with Hashimoto's thyroiditis

11/20/15: A new user with Endometriosis, IBS, Hashimoto's Thyroiditis, Migraine, Gallstone, Gastroparesis, Diverticulosis, Osteoarthritis, Optic Neuritis, High Intraocular Pressure, Uveitis, Iritis, Iris Nodules, Macular Edema, Probable MS, Cataracts, Monoclunus, Monoclonal Gammopothy of Undetermined Significance

11/17/15: New users with Obesity, ADHD,nuropathy / Hashimoto's disease, Lyme disease, Chronic Fatigue Syndrome, Fibromyalgia / Type 1 Diabetes, depression, anxiety, adhd

11/14/15: New users with asthma, cpt2, rls, sleep disorder / ADHD, Gilbert's Syndrome / MCTD, SLE, CFS, EBV with besting working medicine KLONOPIN, SOMA

11/10/15: A new user with EDS Type 3

11/8/15: A new user with Asthma

11/7/15: New users with fibromyalgia, PCOS,CFS,hypothyroid / Asthma

11/5/15: New users with  asthma, eczema /  Cluster headaches

11/3/15: New users with Crohn's disease, asthma, cataracts, depression, / Type 1 diabetes

10/29/15: New users with Epilepsy / Bipolar disorder / Depression

10/27/15: A new user with ITP, hypothyroidism, SLE, Type 2 diabetes, hypermobility

10/24/15: New users with Type II Diabetes, Polycystic Ovarian disease, Hypothyroidism, Bipolar with hypomania, Schizotypal disorder, Anxiety disorder / ADHD,PTSD,ANXIETY

10/20/15: New users with SLE, Fibromyalgia, Central Sleep Apnea / Crohn's disease

10/19/15: A new user with gluten intolerance

10/18/15: A new user with dermatomyositis, arthritis

10/16/15: A new user with Asthma

10/15/15: A new user with Hashimoto's Thyroiditis

10/14/15: A new user with Bipolar

10/13/15: A new user with Type II Diabetes, Hyperstension, Hypercholesterolemia

10/12/15: A new user with anxiety and gestational diabetes

10/10/15: A new user with Chronic Eczema

10/9/15: A new user with Type I diabetes and Atrial fibrillation

10/7/15: A new user with depression

10/6/15: A new user with Atrial fibrillation, Tricuspid Atresia

10/3/15: A new user with allergies, IBS, fibromyalgia

10/2/15: New users with Chronic Lymphocytic Leukemia /  ulcerative colitis, cystitis / carotis stenosis

10/1/15: New users with ADHD, Keratoconus / depression

9/30/15: A new user with Rosacea

9/28/15: New users with hidradenitis, Type II diabetes, hypothyroidism, depression, anxiety / Varicocele

9/26/15: A new user with Von Willebrand's disease, Hashimoto's disease, cholelithiasis

9/25/15: A new user with ADD

9/23/15: A new user with Depression, Hypertension, Hypogonadism with best working medication: zoloft,Lisinopril,testosterone cypionate 

9/22/15: A new user with Hereditary Hemochromatosis

9/17/15: New users with depression, OCD / Crohn's disease

9/15/15: New users with childhood asthma / pernicious anemia, depression / ankylosing spondylitis

9/13/15: A new user with asthma, ADHS, allergies

9/12/15: A new user with hypertension, high cholesterol, thyroid disease

9/9/15, 9/10/15: A new user with Depression

9/8/15: New users with Burkitts lymphoma / adhd, aspergers, anxiety / Bipolar, Deppression, ADD

9/5/15:  leaky gut, candida, anemia / Celiac disease

8/31/14: New users with Type II diabetes, hypertension, hypothyroidism, hyperlipidemia, obesity, bipolar disorder, major depression, sleep apnea / Atrial fibrillation / gout, hemachromatosis, sudden sensineuronal hearing loss

8/24/15: A new user with IBS

8/23/15: New usres with Celiac disease / Multiple sclerosis

8/22/15: A new user with anxiety, panic disorder, ocd, depression

8/19/15: New users with Ehlers-Danlos Syndrome, Postural Orthostatic Tachycardia Syndrome, Mast Cell Activation Syndrome, Asthma, BRCA1 / Miagraine

8/14/15: A new user with SLE-Lupus, Alpha 1 Anti-tyrpsin Deficiency, Hypogammaglobulinemia / best working medicationPlaquenil, Provigil

8/13/15: A new user with insomnia

8/12/15: A new user with  adhd, varicose veins

8/9/15: A new user with  Aortic Stenosis

8/8/15: A new user with Graves diease

8/6/15: New users with GERD / ADHD, depression

8/3/15: A new user with hemiplegic migraine, anxiety, panic disorder, agoraphobia, depression, multidirectional instability, patellofemoral inflammation

7/30/15: A new user with POTS

7/26/15: New users with Myelitis, Psoriasis, possibly Malign Melanoma, PCO / mitral valve prolapse, prediabetes, IC /  thyroid cancer, gluten ataxia with best working medication: LDN

7/21/15: A new user with Epilepsy

7/19/15: New users with Asthma, psoriasis, ADD / hypertension, high cholesterol

7/18/15: A new user with hypothyroidism, dermititis, anxiety

7/14/15: New users with Dysthemic depression, PTSD / Crohn's disease

7/13/15: New users with Glioblastom, Glioma, Brain Cancer / Hypertension

6/27/15-7/11/15: New users with depression / systemic lupus variant with features of M.S. and M.G., dystonia (spasmodic torticollis), classical Ehlers-Danlos syndrome, von Willebrand's disease, atrial fibrillation, suspected neuroendocrine tumors, sudden onset sensineural hearing loss / non-celiac gluten intolerance, IBS, ADHD inattentive, ptsd / Type 2 Diabetes, Hypertension / hypothyroidism /  ulcerative colitis / Crohn's disease

6/26/15: A new user with Atrial fibrillation

6/21/15: New users with hypothyroidism / Scoliosis / Eczema, Allergies

6/16/15: A new user with  Migraine, GERD, Arthritis

6/11/15: New users with Hypothyroid, Kidney disease / Asthma, allergies, BPH

6/10/15: A new user with Acne, High Cholesterol, Anxiety

6/9/15: A new user with depression and social anxiety

6/8/15: A new user with cervical dysplasia and adhd

6/6/15: New uses with Bipolar Affective Disorder / Lyme disease

6/4/15: A new user with hypertension

6/3/15: A new user with Hypertension, Sleep Apnea, Obesity

6/1/15: A new user with high blood pressure

5/30/15: A new user with Asthma

5/29/15: A new user with fibromyalgia, hypothyroid, hypertension 

5/28/15: A new user with Type 2 diabetes

5/27/15: A new user with Hashimoto's and PCOS

5/25/15: A new user with endometriosis, gallstones

5/24/15: A new user with spasmodic dysphonia, keratocone

5/23/15: A new user with hypertension and gout

5/22/15: New users with Type 2 diabetes, high blood pressure, gene that cause Loeys Dietz Syndrome TGFBR2 with variant p.Cys138Gly, Cervical Stenosis, Osteoarthritis, Fibromyalgia / Asthma, Allergy

5/17/15: A new user with goiter

5/15/15: A new user with lupus, interstitial cystitis 

5/14/15: New users with Crohn's disease; connective tissue disease / Diabetes

5/12/15: A new user with High Cholesterol, Acne

5/11/15: New users with petit Mal epilepsy, hypertension, fuchs / Asthma / ADHD / Hypothyroidism

5/9/2015: New users with Breast cancer / Hypothyroidism and Lyme's disease

5/7/2015: A new user with Asthma

5/6/2015: New users with Asperger's Syndrome, Gilbert Syndrome, Irlen Syndrome, ADHD / PCOS

5/5/2015: New users with hiatal hernia, esophageal motilitydisorder,GERD, depression, plantar faciatis / hypertension (best working medication: losartan), gout (best working medication: allopurinol)

5/4/2015: A new user with ADHD, heart murmur, mitral valve prolapse, panic disorder

5/1/2015: New users with ADD (best working medication: ritilin) /  IBS, Mastocytosis, A-Fib, Hypogonadism, Hypothyroidism

4/30/2015: New users with Type 2 diabetes, Hypertension, Fibromyalgia, Migraine / Asthma

4/29/2015: A new user with Asthma and ADD 

4/28/2015: A new user with depression (Best working medication: Prozac), ADHD (adderall), hypermobility

4/27/2015: A new user with Type I diabetes, high blood pressure, high cholesterol, sleep apnea, hypogonadism

4/26/2015: New users with Type II Diabetes, Hypertension, Hypothryoid, Depression / Narcolepsy

4/25/2015: A new user with Melanoma, ADD, Anxiety Disorder

4/24/2015: New users with Crohn's disease, copd, AAA / Type 1 diabetes

4/23/2015: A new user with micro valve prolapse 

4/20/2015: A new user with narcolepsy, sleep apnea, hypothyroidism, vitamin d deficiency

4/18/2015: New users with Prolactinoma / Asthma

4/17/2015: A new user with Depression/Anxiety, Migraines

4/16/2015: New users with heart failure, left bundle branch block, atrial aneurysm, pfo, brain lesion, adrenal tumor, breast cancer, depression anxiety / Parkinson's, autism, asthma 

4/14/2015: A new user with IBS / high blood pressure with best working medication: benicar 40 mg / gluten intolerence, ADD

4/11/2015: New users with Periodic Limb Movement Disorder and ARVD

4/9/2015: A new user with Crohn's disease

4/8/2015: New users with spina bifida, eczema / ADHD / Hypertension

4/7/2015: New users with Diabetes and Asthma / Asthma

4/6/2015: New users with Polycystic ovaries, tinnitus, sensorineural hearing loss, vertigo, obesity, bipolar, anxiety, GERD / Osteopenia

4/5/2015: New users with Meniere's disease / PCOS / Crohn's Disease / Breast cancer / Asthma, Allergies, Depression, Thalassemia / Migraine / Bipolar disorder, anxiety, BPH, migraines, fibromyalgia, allergies, dry eye syndrome

4/3/2015: New users with neurocardiogenic syncope, MSK / thyroiditis, baldness, depression / myasthenia Gravis, Thymus hyperplasia, thyroidcancer, asthma, lipomas, fibromas, Hemangiomas / Congenital heart defect, pelvic kidney, fused ribs / arthritis / Type 1 Diabetes / Depression

4/1/2015: New users with basal cell carcinoma / Asthma / obesity, low testosterone

3/31/2015: New users with Endometriosis, PCOS /  Hypertension, High Cholesterol (Best working medication: diovan, crestor, respectively)

 3/30/2015: Asthma, ADHD and allergies / Hypotonia / Crohn's disease

3/28/2015: New users with Papillary Cancer / ADHD / Grave's disease

3/27/2015: New users with basal cell cancer / Hypertension / Cervical Dysplaysia

3/26/2015: New users with depression / ADHD and depression

3/25/2015: New users with Psoriasis, ADHD, and PTSD / Crohn's disease

3/24/2015: A new user with Factor V Leiden

3/23/2015: A new user with Crohn's disease

3/20/2015: New users with Tourettes Syndrome, OCD, Exercise Induced Asthma / asthma and appendicitis

3/18/2015: A new user with Degenerative Disc Disease / POTS, Dysautonomia

3/15/2015: A new user with  General Anxiety Disorder, and Major Depression / Depression, ADD /  follicular lyphoma, diffuse large B call lymphoma, kidney stone

3/14/2015: New users with  Ehlers Danlos, Mast Cell Activation Disorder, POTS, Sero-Negative Arthritis, Fibromyalgia / Lyme disease / Dermagaphic Uriticaria

3/12/2015: A new user with Crohn's disease

3/7/2015: A new user with hypothyroid,hashimotos,carpul tunnel, fibromyalgia,orthostatic hypertension

3/6/2015: A new user with asthma, hiatal hernia, melanoma, allergies

3/3/2015: A new user with migraines

2/27/2015: A new user with arachnoiditis, high blood pressure, and spondylosis

2/24/2015: A new user with Hashimoto's 

2/22/2015: New users with  pernicious anemia (best working medication: vitamin b12)  and Type 2 diabetes / fibrositis,myalgia,myositis,arthralgia,polyneuropathy,metabolic myopathy, depression, attention deficit disorder

2/21/2015: New users with Asthma and Gout / Psoriasis / Hashimoto's 

2/20/2015: New users with Asthma / Atrial Fibrillation, depression, asthma, myocarditis, reoccurring septicemia, atrial flutter

2/17/2015: New users with Colon cancer / fecal incontinence; anxiety; depression; GERD, Best working medication: Protonix / Hashimotos, Lyme Disease /  psoriasis, asthma, factor IV leiden

2/16/2015: New users with Crohn's disease and Fibromyalgia / Asthma / Rheumatoid Arthritis / kidney stones and SVT

2/15/2015: New users with ADHD / Crohn's disease and hypothyroidism / Postural Orthostatic Tachycardia Syndrome, Ehler's Danlos, Migraine, Psuedotumor Cerebri, Gastroparesis, May Thurner's, Post-Thrombitic Syndrome, Depression, Anxiety, Post Traumatic Stress Disorder

2/14/2015: New users with Gastroschisis, bipolar,depression / Fibromyalgia, PCOS, Endometriosis, TMJ, Hypothyroid, Ulcerative Colitis, GERD

2/13/2015: New users with Lymphoma / Lyme disease / MTHFR deficiency

2/12/2015: New users with Trigger Thumb and Plantar Fibroma / Fatty Liver  and High blood pressure /  chronic renal disease

2/11/2015: A new user with Rheumatoid arthritis

2/10/2015: New users with Myopia / Depression

2/9/2015: A new user with hypothyroidism

2/8/2015: A new user with Crohn's disease; Best working medication: Humira

2/5/2015: A new user with Postural Orthostatic Tachycardia Syndrome, Dysautonomia, Mast cell activation disorder, Depression

2/3/2015: New users with depression and anxiety / depression

2/2/2015: New users with pseudohypoaldosteronism type 1 / Hypothyroidism, fructose malabsorption

1/31/2015: A new user with Panic Disorder, Migraines, Vitamin D Deficiency, Premature Ventricular Contractions PVC's, Fibromyalgia

1/29/2015: New users with obsessive-compulsive disorder / Alopecia areata, Spondylitis ankylopoetica / Alzheimer's disease (early), crohn's disease, pre-esophageal cancer

1/28/2015: New users with Hypothyroidism / Polycystic ovary syndrome

1/26/2015: New users with Asthma, cervical dysplasia /  idiopathic intracranial hypertension, migraines, depression, anxiety; best working medication: diamox, depakote, Effexor, pristiq 

1/25/2015: New users with hypertension, depression, hyperlipidemia / Type 2 diabetes /  systemic lupus, depression, migraines, anxiety, sjogren's syndrome / Degenerative Disk Disease, Emphasema, High Blood Pressure

1/24/2015: New users with Hypothyroidism and Androgenetic Alopecia / Autoimmunune Thyroiditis, Attention Deficit Hyperactivity Disorder, Depression, Anxiety, and Bulimia Nervosa /  systemic lupus erythematosus, psoriasis, fibromyalgia, and anxiety

1/22/2015: New users with Asthma & Allergies / ADHD & Depression / ADHD

1/21/2015: Two new users with Asthma / A new user with ADD

1/20/2015: A new user with depression; best working medication: duloxitene

1/18/2015: New users with Grave's disease or Polycystic ovary syndrome

1/15/2015: A new user with Multifocal motor neuropathy 

1/13/2015: New users with Bipolar disorder /  Neurocardiogenic Syncope, Trigeminal Neuraglia /  B-Cell Non-Hodgkins Lymphoma

1/10/2015: New users with Alpha Thalassemia Trait, Hypovitaminosis D, Generalized Anxiety Disorder, and Spontaneous Ovarian Hyperstimulation Syndrome / Hypertension, Hypercholesteremia, Testicular Ectopy,  and Vitamin D defficiency / Ulcerative Colitis 

1/8/2015: New users with Crohn's disease or prostatitis

1/7/2015: New users with GERD, hypertension, ADHD or Hypothyroidism

1/3/2015: Two new users with Asthma / A new user with polycystic ovarian syndrome / A new user with thyroid disease

1/1/2015: New users with Allergy, Herpes, vitamin D deficiency and Colitis / Endometriosis, essential tremor, mitral valve prolapse, and loin pain hematuria / hypertension and acid reflux disease / Polycystic ovarian syndrome

12/30/2014: A new user with ADHD

12/29/2014: A new user with IBS, allergies, gluten intolerance, mixed connective tissue disease and MTHFR 

12/28/2014: A new user with Type 2 diabetes 

12/25/2014: A new user with high blood pressure and high cholesterol

12/17/2014: A new user with Lichen sclerosus and best working medicine: betamesthasone 

A new user with hypothyroidism

12/16/2014: A new user with hypothyroidism

12/12/2014: New users with gallbladder and hypertension / prediabetes, hyperinsulinemia, and hashimoto thyroiditis

12/10/2014: A new user with acne vulgaris and insertional tendinopathy

12/8/2014: A new user with Hashimoto's Thyroiditis

12/6/2014: A new user with Hypothyroidism

12/4/2014: A new user with ADHD

12/3/2014: A new user with Mitral valve prolapse and migraines

12/2/2014: A new user with Crohn's disease & Best working medicine: Remicade, 6-Mercaptopurine

12/1/2014: A new user with Gastroesophageal reflux disease / Best working medicine: Nexium; A new user with Hypersomnia; A new user with Ehlers-Danlos snydrome, Postural orthostatic tachycardia syndrome and chronic fatigue syndrome

11/26/2014: A new user with ADD

11/20/2014: A new user with Crohn's disease and Nonalcoholic fatty liver disease

11/25/2014: A new user with Degenerative disc disease

11/24/2014: A new user with renal lithiasis and rosacea

11/22/2014: A new user with Ulcerative Colitis

11/19/2014: A new user with Supraventricular tachycardia, Atrial fibrilation and endometriosis

11/18/2014: New diagnosed information in Hypothyroidism, Irritable bowel syndrome and Fibromyalgia (huA8DD58)

11/16/2014: A new user with Scoliosis, Sleep Apnea, Bipolar disorder, Narcolepsy, Cat Allergies and Asthma

11/14/2014: A new user with male pattern baldness

11/12/2014: New users with Gastroparesis and Hashimoto's / Kidney stones

11/11/2014: New users with Crohn's DiseaseHashimoto's Thyroiditis

11/10/2014: New users with Dermatofibrosarcoma protuberans / Allergy

11/9/2014: A new user with Type 1 diabetes

11/8/2014: A new user with Narcolepsy, Depression and Hip dysplasia

11/6/2014: A new user with Polycystic ovary syndrome

11/4/2014: A new user with Triple X Syndrome, Anxiety, IBS and Dysautonomia

11/2/2014: A new user with depression

10/31/2014: A new user with Fibromyalgia

10/29/2014: New users with hypogonadism / Aspergers Syndrome, Chronic Anemia, Insomnia, and Restless Leg Syndrome

10/28/2014: A new user with  microscopic colitis 

10/27/2014: A new user with multiple sclerosis 

10/25/2014: Two new users with Crohn's disease

10/23/2014: A new user with Hypertension 

10/22/2014: New users with Hypothyroidism / Hypercholesterolemia /  dupuytren's contracture 

10/20/2014: A new user with  ADD, Anxiety, and GERD

10/19/2014: New users with Ovarian cancer / Asthma

10/16/2014: A new user with Asthma

10/15/2014: A new user with  Hashimoto's thyroiditis and essential tremor / Allergies and Eosiniphilic Esophagitis

10/14/2014: A new user with diagnosed Ehlers-Danlos Syndrome, Myopia, Panic Disorder with Agoraphobia and Rheumatoid Arthritis

10/14/2014: A new user with diagnosed Arrhythmia, ecephalitis, high blood pressure, psoriasis, and radiculitis

10/12/2014: A new user with diagnosed P.A.N.D.A.S and OCD

10/11/2014: A new user with diagnosed Crohn's disease and psoriatic arthritis

10/10/2014: New diagnosed information in Lipoma (hu938B7C)

10/7/2014: A new user joined with diagnosed Sarcoidosis

10/4/2014: A new user joined with diagnosed Asthma

10/1/2014: A new user joined with diagnosed Hashimoto's disease

9/29/2014: A new user joined with diagnosed bladder cancer

9/28/2014: A new user joined with diagnosed myalgic encephalomyelitis and chronic fatigue syndrome

9/25/2014: A new user joined with diagnosed Rheumatoid arthritis and Lyme disease

9/23/2014: A new user joined with diagnosed hypothyroidism

9/23/2014: New diagnosed information for Lipoma and Rheumatoid arthritis (hu60AB7C)

9/22/2014: A new user joined with diagnosed Pernicious Anemia and Partial IgA Deficiency

9/18/2014: New diagnosed information for Crohn’s disease, Atrial fibrillation, Asthma and Non-Melanoma skin cancer (hu911FDC)

9/17/2014: A new user joined with diagnosed heart disease, arthritis and factor V Leiden

9/16/2014: A new user joined with diagnosed mixed connective tissue disease,depression and hashimoto's disease

9/14/2014: A new user joined with diagnosed ulcerative colitis, Hashimoto's, GERD, vestibulodynia and osteopoenia

9/13/2014: A new user joined with diagnosed Bicuspid Aortic Valve, Aortic Coarctation, Myopia, Chronic Fatigue Syndrome and Asthma

9/11/2014: A new user joined with diagnosed Mast Cell activation syndrome, eosinophilic esophagitis, gastritis and neurocardiogenic syncope.

9/10/2014:  New diagnosed information in Breast fibroadenoma, Complex Ovarian cysts, Irritable bowel syndrome, Osteoarthritis, Asthma, and Cardiac Arrhythmia (huD37D14)

9/8/2014: A new user joined with diagnosed Crohn's disease

9/7/2014: A new user joined with diagnosed gallbladder or osteoporosis

9/6/2014: A new user joined with diagnosed Ulcerative colitis

9/4/2014: New users joined with diagnosed Autism or Irritable Bowel Syndrome

8/24/2014: A new user joined with diagnosed ADHD

8/20/2014:  New diagnosed information in Restless legs syndrome and Eczema (hu8602F1)

8/17/2014:  New diagnosed information in Endometriosis (hu11DF5B)

8/16/2014:  New diagnosed information in Hypothyroidism (hu7DE7FD)

8/14/2014:  New diagnosed information in Asthma (hu63EB0A & hu1712BC), Arthritis, Uterine fibroid, Ulcerative colitis (hu1712BC), and Cardiac Arrhythmia (huCFD853)

8/10/2014: A new user joined with diagnosed arthritis and hyperlipidemia.

A new user joined with diagnosed hypothyroidism.  

8/6/2014: New users joined with diagnosed Type 2 diabetes, Sleep ApneaMeningioma, High Cholesterol, High Blood Pressure, Supraventricular Tachycardia, depression, and anxiety

8/4/2014: New users joined with diagnosed ADHD and Basal cell carcinoma

8/2/2014:  New diagnosed information in Attention Deficit Disorder (huAB46EB)

7/31/2014: A new user joined with diagnosed hemachromatosis  & migraines / New diagnosed information in Type 2 diabetes and Restless legs syndrome (hu9FEC32)

7/30/2014: A new user joined with diagnosed Atrial fibrillation & Type 2 diabetes / New diagnosed information in Hypothyroidism, Asthma and Restless legs syndrome (huA110DA)

7/29/2014: New diagnosed information in Restless legs syndrome (hu2E179F and hu790518)

7/23/2014: A new user joined with diagnosed Crohn's disease / new diagnosed information in Type 2 diabetes & Dupuytren's disease (hu2A4D22) and Asthma (hu5CABA7)


7/19/2014: The users with two Ts in rs2200733 were marked with "High Risk" in Atrial fibrillation based on 23andme curation and the following reference (read more):

Kääb et al. (2009) . “Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation.” Eur. Heart J. 30(7):813-9.

This paper says: 

"Single nucleotide polymorphism (SNP) rs2200733 was associated with AF in all four cohorts, with odds ratios (ORs) ranging from 1.37 in Rotterdam [95% confidence interval (CI) 1.18–1.59; P = 3.1 × 10−5] to 2.52 in AFNet (95% CI 2.22–2.8; P = 1.8 × 10−49)."
"A meta-analysis of the current and prior AF studies revealed an OR of 1.90 (95% CI 1.60–2.26; P = 3.3 × 10−13) for rs2200733"
 

 7/19/2014: A new user joined with Diagnosed Multiple sclerosis and Hypothyroidism / New diagnosed information in Eczema, Polycystic ovary syndrome and Cardiac arrhythmia (huE07725)

7/18/2014: New diagnosed information in Asthma (hu3F37F2, hu43294F), Melanoma (huDDA29F), Restless legs syndrome (huDDA29F, hu43294F), Atrial fibrillation (huDDA29F, hu43294F), Polycystic ovary syndrome (hu7504E8, hu3F37F2), Celiac disease (hu43294F), Eczema (hu43294F, hu3F37F2), Hypothyroidism (hu3F37F2)  and Type 2 diabetes (hu3F37F2)

 

7/15/2014: New diagnosed information in Bipolar disorder (huE8E4FChu5DE8CD and hu443DE9), Asthma (hu5DE8CD)  and Type 2 diabetes (huE8E4FC)

7/14/2014: A new user joined for diagnosed GERD and Sleep Apnea / New diagnosed information in Asthma (huC93106 and hu80AD0F) and Eczema (huC93106)

7/10/2014: New diagnosed information in ADHD and Bipolar disorder (huDD1522) / New diagnosed information in Asthma, Atopic dermatitis, Restless legs syndrome and Endometriosis (hu72076D)

7/9/2014: New diagnosed information in Asthma (huE9E777), Hypothyroidism (hu45AE46), Uterine fibroids (hu84787F), and Restless legs syndrome (hu84787F)

7/8/2014: New diagnosed information in Asthma (huE2D0CA) and Endometriosis (huC4A276). 

7/7/2014: A new user joined for diagnosed ADD. 

7/5/2014: New diagnosed information in Rheumatoid arthritis, Endometriosis and Utrine fibroids (hu117D1E)

7/4/2014: A new user joined with family history in Asthma. / A new user joined for diagnosed Migraines, ADHD, Convergence insufficiency, and obesity & family history in heart disease, diabetes, breast cancer, hypertension, and obesity

7/3/2014: A new user joined for diagnosed Mitchell's disease and Rheumatoid arthritis. / New diagnosed information in Melanoma and Prostate cancer / A new user joined for diagnosed Sjogren's Syndrome and Rheumatoid arthritis & family in Hashimoto's disease and Lupus. 

7/1/2014: New diagnosed information in hypothyroidism & family history in Crohn's disease and heart disease

6/29/2014: A new user joined for diagnosed Antiphospholipid syndrome, Psoriasis, and Coronary microvascular disease & family history in Breast Cancer and Parkinson's disease

6/27/2014: A new user joined for diagnosed ADHD, Obsessive-Compulsive disorder, and Panic Disorder / A new user joined for diagnosed Ehlers danlos syndrome, collagen disorders, and degenerative disc disease & family history in diabetes, Aneurysm, depression, cancer, heart attack, and arrhythmias

6/26/2014: A new user joined for diagnosed Hypersomnia, Childhood Absence Seizures, and Myopia &  Family history in Atrial fibrillation, Ulcerative Colitis, Celiac, Allergies, and Immune disordersA new user joined for fibromyalgia and MTHFR & Family history in diabetes / A new user joined with family history in Parkinson's and Type II Diabetes

6/25/2014: A new user joined for diagnosed Hypothyroidism, protein s deficiency, mthfr, heart murmur, miscarriages, and stillbirth & family history in high blood pressure, prostate cancer, and atrial fibrilation

6/24/2014: A new user joined for diagnosed Hypothyroidism and family history in Lung cancer, heart disease and depression / A new user joined for diagnosed Type 2 Diabetes / A new user joined for diagnosed Dysautonomia, Neurocardiogenic syncope, Hypothyroidism, Endometriosis, and Gastroparesis

6/22/2014: A new user joined for diagnosed Celiac disease; family history in Celiac disease and Colon cancer

6/20/2014: A new user joined for diagnosed Polycystic kidney disease / Diagnosed information for Ovarian Cysts: hu117D1E huBE12FC and dignoased huD3D99C in Polycystic ovary syndrome / Diagnosed information for Atopic dermatitis (Eczema): hu1843FC

6/18/2014: A new user joined for diganosed Pyloric stenosis.

New diagnosed information added for hu313730: Polycystic ovary syndrome (PCOS), Lactose intolerance, Irritable Bowel Syndrome, Gallbladder Removal, and Iron deficiency anemia / For huD2F73D, Gilbert syndrome and Raynaud's phenomenon  / For hu3DC5EA, Thyroid nodule(s), Hypothyroidism, Iron deficiency anemia, Urinary tract infection (UTI), Myopia (Nearsightedness), Astigmatism and Pilonidal cyst

6/12/2014:  A new user with diagnosed Common Variable Immunodeficiency and Asthma / A new user with family history in AAT and Congestive heart failure. 

6/6/2014: A new user with diagnosed Pectus excavatum, Mitral Valve Prolapse and Diabetes Mellitus from personalgenomes.org

5/29/2014: A new user with diagnosed Uterine fibroids and Cervical dysplasia from personalgenomes.org

5/10/2014: A new user joined for high risk Chronic Kidney Disease, Colorectal Cancer, Ulcerative Colitis and Crohn's Disease.

5/7/2014: A new user joined for diagnosed High blood pressure, Gluten Intolerance, and Seasonal Allergies.

5/6/2014: A new user joined for diagnosed Factor V Leiden, and Parkinson's disease and Factor V Leiden in family history.

4/30/2014:  A new user joined for diagnosed Multiple sclerosis and Atrial fibrilation, concerned Fibromyalgia, and Breast cancer in family history.

4/23/2014:  A new user joined for diagnosed childhood asthma and dyslexia, and family history in dyslexia.

4/22/2014: A new user joined for diagnosed celiac disease, dysautonomia, MGUS, fructose intolerance, and peripheral neuropathy. 

4/8/2014: A new user with diagnosed microscopic colitis

3/31/2014: A new user with family history in connective tissue

3/20/2014: A new user with diagnosed Biliary Atresia, Gastroesophageal Reflux(GERD) and family history in Type 2 Diabetes

3/17/2014: User with family history added in Type 1 Diabetes

2/11/2014: User with family history added in Breast Cancer. 

1/29/2014: User with family history added in Type 2 Diabetes. 

1/26/2014: Diagnosed/Family history user added in Breast cancer, Lung cancer and Asthma. 

12/27/2013: Diagnosed user added in Type 2 Diabetes

11/11/2013: New diagnosed information in Uterine fibroids

10/18/2013: Lymphoma added in GeneKnot

10/15/2013: New diagnosed information in Bipolar disorder, Rheumatoid arthritis, and Restless Legs Syndrome.

10/13/2013: Eating disorder is added to GeneKnot. "Diagnosed" is added to Atopic dermatitis. 

10/10/2013: The information with diagnosed restless legs syndrome is added.

10/7/2013: Diagnosed users for Prostate cancer, Breast cancer, Melanoma, Hypothyroidism, Ulcerative colitis, Asthma and Age-related macular degeneration are added 

10/1/2013: A user with "Related" symptom is added to Type 2 diabetes.   

9/29/2013: A user with "Diagnosed" symptom is added to Rheumatoid arthritis. A user with "Related" disease is added to Ankylosing spondylitis.  

9/23/2013: You can compare your genetic distances from users with diagnosed diseases or high risk DNA variants. Go to "GeneKnot" menu (login required) and type "Diagnosed", "High-Risk", "Family-History", "Related", or "Concerned" diseases in a search window. If you're close to them, you can ask about their experience. We'd like to thank GeneKnot users for valuable information!

The information is available in Asthma (Diagnosed), Breast Cancer (Diagnosed), Type 2 diabetes (Diagnosed & Concerned), Atrial fibrillation (High-Risk & Related), Parkinson's disease (High-Risk & Concerned), Bipolar disorder (High-Risk), Bladder cancer (Family-History), Rheumatoid arthritis (Family-History & Concerned), Hypothyroidism (Related), Atopic dermatitis (Related), Restless legs syndrome (Related), Coronary heart disease (Related & Concerned), Age-related mascular degeneration (Concerned), Alzheimer's disease (Concerned), Melanoma (Concerned), and Type 1 diabetes (Concerned).

8/1/13 : Odds ratios with less than 10E-5 in p-values are selected for a Disease Risk menu