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My 23andMe trio data: Your family's risk?

My family's 23andme data for my wife and son arrived. Now I have my family's trio data!

I was really curious about a few diseases in which my son might have a high genetic risk due to my high risk SNPs.

Atrial fibrillation (AF): I have 1.73 in odds ratios and that gives 27.2% (average) * 1.73 = 46.9% of probability to develop this disease in my lifetime (read more).  I had chest pain in my late 30s and had no idea what caused that. I used to drink a couple of cups of coffee everyday. Since I got 23andMe reports and did some research about AF, I have switched to decaffeinated coffee and also reduced alcohol consumption. My chest pain almost disappered. If my chest pain was really due to AF, I guess 23andme results really helped me prevent AF from getting worse.    

I hoped that my wife's SNPs would mitigate my son's risk in AF. But the most surprising part was that my wife also has a high risk (1.93). Her probability of developing AF is 15.9% * 1.93 = 30.7%. The average risk is lower for women (15.9%) than men (27.2%) in 23andMe. It turns out that my son has the same risk of mine (1.73).

23andMe uses only two SNPs from European studies for AF:

1. rs10033464 GG (my genotype) European: 0.92 

2. rs2200733 TT (my genotype) European: 2.57

My son got SNPs related to AF from my wife and me as follows in GeneKnot (Overlapped SNPs with 23andme are underscored):

  • rs2040862-T : 0 (dad 0 + mom 0)
  • rs13376333-T : 0 (dad 0 + mom 0)
  • rs1152591-A : 1 (dad 0 + mom 2), My son got one of mom's SNP.
  • rs10033464-T : 0 (dad 0 + mom 0)
  • rs3807989-G : 2 (dad 2 + mom 2), My son got one from dad and one from mom.
  • rs6843082-G : 2 (dad 2 + mom 2)
  • rs7193343-T : 2 (dad 2 + mom 2)
  • rs2106261-T : 1 (dad 2 + mom 0), My son got one from dad. 
  • rs2200733-T : 2 (dad 2 + mom 2)
  • rs6817105-C : 2 (dad 2 + mom 2)
  • rs17042171-A : 2 (dad 2 + mom 2)
  • rs7164883-G : 2 (dad 1 + mom 1)
  • rs10824026-A : 2 (dad 1 + mom 2), My son got one from dad and one from mom.

 This is like Genetics101, but it's kind of cool to see how my son got his SNPs from my wife and me. Unfortunately my wife and I both have a high risk in AF and do not mitigate my son's risk. Now AF becomes my family's high risk disease. In a postive side, we can let my son know that caffeine may cause his chest pain. We can do preventive care against AF all together.

My family shown in GeneKnot are clearly distinguishable from other members. One closest user is Agron_Daja. I wish that I could communicate with this user. But his data is from OpenSNP. I don't have his direct contact information. Hopefully we can talk about symptoms and treatment when more people with similar SNPs join.    

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I have several interesting findings in my trio data, but I'll introduce one more example to give you an idea of what you can expect from your trio data.

Bladder cancer: My father had bladder cancer in his late 60s (read more).

Since I had bad news in AF, I was a little nervous to check my family's bladder cancer risk.

Although 23andMe reports my bladder cancer risk as "Slightly higher odds", I am worried because 23andme results are from preliminary studies and I have relatively many risk alleles. 

My son's SNPs are as follows: 

  • rs2294008-T : 1  (dad 2 + mom 0) my son got one from dad.
  • rs798766-T : 1 (dad 0 + mom 1) my son got one from mom.
  • rs8102137-C : 0 (dad 0 + mom 0)
  • rs710521-A : 0 (dad 0 + mom 0)
  • rs401681-C : 2 (dad 2 + mom 1) my son got one from dad and one from mom.
  • rs9642880-T : 2 (dad 2 + mom 2)

My son has one less rs2294008-T than me, but one more rs798766-T. His SNPs appear to be closer to mine than my wife's. At this point it's not clear how this difference would affect the overall risk of bladder cancer. I just hoped that my son's SNP profile is closer to my wife's since my father had bladder cancer. Is it another bad news? I guess that it could be better. But as long as we're aware of our risk, screening and preventive care would be enough to stay healthy. It's pretty interesting to explore my trio data. How close is your child's genetic risk to yours?   

- See more at: https://geneknot.com/mds#images/Bladder_cancer_user_snp_scores.gexf (login required)

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